These two women served as laborers in the Christian community at Philippi, a roman city in northeastern Greece. The municipality was important because it was situated between the Via Egnatia (a well-traveled road that ran from the Adriatic coast to Byzantium) and the fertile agricultural plain in the shadow of Mt. Pangaeus. In the Apostle Paul's letter to the Philippians (which he wrote from prison), reference is made to Euodia and Syntyche, two women belonging to the congregation in Philippi.

This is the only place the women are mentioned in the Bible. Little else is known about them, except that they were working on behalf of the Lord, but were not in accord with each other, possibly over the Scripture or Christian teaching.