Drusilla, a gorgeous Jewess who belonged to a powerful family of officials working for the Roman Empire, became known as an immoral woman and an adulterer who was unrepentant to the end of her life. Her father was Herod Agrippa I, and her uncle was Herod Antipas, the man who ordered the beheading of John the Baptist. Drusilla was the loveliest and the youngest of her three sisters. At the age of fifteen, she married King Aziz after his conversion to Judaism. She soon became an unfaithful wife, turning her attention to the Roman governor Felix, who abducted her. She married him; however, the marriage was not legal, since Drusilla was neither divorced nor widowed. Drusilla took Felix as a husband, although he was a heathen and not inclined to convert to Judaism. In fact, he was a former slave whose savagery and brutality helped him move up the ladder of power to provincial ruler. The marriage cemented Drusilla's reputation as an immoral woman.

Drusilla was present when Felix called the Apostle Paul before him to answer charges by Jews of being a “pestilent fellow, and a mover of sedition among all the Jews throughout the world, and a ringleader of the sect of the Nazarenes: Who also hath gone about to profane the temple” (Acts 24:5–6). The couple listened as Paul reasoned out righteousness, temperance, and the judgment to come. He spoke of his faith in the Christ. Felix, the Bible says, began to tremble, suggesting that his heart may have received the Apostle's holy words, and that Paul's teaching had a powerful effect. Perhaps Felix felt remorse for all of the bad things he'd done. Maybe he regretted abducting and marrying Drusilla. He might have converted, some say, if Drusilla hadn't been present. Felix abruptly told Paul to go, and that he would call him later in a “convenient season” (Acts 24:25).

Some biblical writers suggest that Drusilla may have wanted the meeting to end. Perhaps the Apostle's words had made her uncomfortable and forced her to recall her sins. Whatever happened that day, the meeting ended and the Apostle Paul was returned to prison. Felix sent for Paul often and communed with him, but it is unclear what happened to Drusilla after that meeting; references to her in the Bible stop at that point. After two years, Felix transferred Paul's case to Procius Festus for trial against the charges the Jews had levied against the apostle. According to one source, Drusilla died some twenty years later with her child Agrippa, trying to flee the eruption of Mount Vesuvius.