When you think of a vacation to Italy, the Colosseum and Michelangelo's Sistine Chapel immediately come to mind. Both are located in the capital city of Rome, which was once the center of all Western civilization. Thousands of years' worth of history are here, including an old city center that is a UNESCO World Heritage Site. There is a pleasantly modern transportation infrastructure that makes the city easy to get around, as well as countless options for hotels and restaurants at all price points.