Pharmacologists who work for the FDA review and evaluate the pharmacological and toxicological data contained in new drug applications (NDAs) and investigational new drug applications (INDAs). FDA pharmacologists review the results of preclinical pharmacological and toxicological studies submitted in support of NDAs and INDAs. In addition, they assess the safety of drugs based on toxicity experiments conducted by the investigator. FDA pharmacologists then prepare a summary of data reviewed and submit recommendations and conclusions for approval.

The grade levels at which these positions are most commonly filled are GS-9 ($38,175) through 15 ($91,507) at the headquarters level. Prerequisites for all grades in this position include a degree with a major in pharmacology or in a biological, medical, veterinary, or physical science, including a minimum of thirty semester hours in chemistry and physiology and twelve semester hours in pharmacology. Pharmacologists are located only in the headquarters, not in field offices.