Unfortunately, treating fatigue is not easy. Antidepressants and hypnotics, for instance, may be prescribed to help promote sleep. Stimulants or anticonvulsants can sometimes relieve cognitive problems. Some herbal products, such as malic acid or ginseng, may help pick you up. If your fatigue is accompanied by gastrointestinal disorders, you may need an antispasmodic or antianxiety medication. Unfortunately, there are no medications just for physical fatigue.

Whatever medications you are prescribed, take them with caution. People with CFIDS often are unusually sensitive to medications and may need to start on lower-than-usual dosages. In some cases, your doctor may start you on doses below what is considered therapeutic and then gradually work up to a dosage that is of greater benefit. Also keep in mind that medications are not your only treatment option. In some cases, you might benefit from occupational therapy, which can teach you new ways of doing things. Physical therapy can help you with exercises that promote relaxation and reduce muscle tension. You should also consider meditation and other stress-reducing strategies, which can help relieve muscle tension as well.